Scientific Publications

Characterization of sulopenem antimicrobial activity using in vitro time-kill kinetics, synergy, post-antibiotic effect, and sub-inhibitory MIC effect methods against Escherichia coli and Klebsiella pneumoniae isolates

Joshua M. Maher, Michael D. Huband, Jill M. Lindley, Paul R. Rhomberg, Steven I. Aronin, Sailaja Puttagunta, Mariana Castanheira

Feb 5, 2025

A phase 3 randomized trial of sulopenem vs. ertapenem in patients with complicated intra-abdominal infections

Michael W. Dunne, Steven I. Aronin , Anita F. Das, Karthik Akinapelli, Jeanne D. Breen, Michael T. Zelasky, Sailaja Puttagunta

Nov 2, 2024

Oral β-Lactam Pairs for the Treatment of Mycobacterium avium Complex Pulmonary Disease

Dereje A Negatu, Sung Jae Shin, Su-Young Kim, Byung Woo Jhun, Véronique Dartois, Thomas Dick

Dec 27, 2023

Sulopenem Disk Development, Quality Control Range, and MIC to Disk Result Correlation for Enterobacterales Isolates

Sailaja Puttagunta, Steven I. Aronin, Jeanna DiFranco-Fisher, Laura Koeth 

Jun 26, 2023

In vitro activity of sulopenem and comparator agents against Enterobacterales and anaerobic clinical isolates collected during the SENTRY Antimicrobial Surveillance Program

Joshua M. Maher, Michael D. Huband, Christopher G. Blankers, Sailaja Puttagunta, Steven I. Aronin and Mariana Castanheira

Apr 12, 2023

In vitro activity of sulopenem against 1880 bacterial pathogens isolated from Canadian patients with urinary tract infections

Andrew J. Walkty, James A. Karlowsky, Melanie R. Baxter, Philippe R. S. Lagace-Wiens, Heather J. Adam, and George G. Zhanel

Sep 30, 2022

Sulopenem or Ciprofloxacin for the Treatment of Uncomplicated Urinary Tract Infections in Women: A Phase 3 Randomized Trial

Michael W Dunne, Steven I Aronin, Anita F Das, Karthik Akinapelli, Michael T Zelasky, Sailaja Puttagunta, Helen W Boucher

Sep 7, 2022

Sulopenem For The Treatment of Complicated Urinary Tract Infection Including Pyelonephritis: A Phase 3 Randomized Trial

Michael W Dunne, Steven I Aronin, Anita F Das, Karthik Akinapelli, Jeanne Breen, Michael T Zelasky, Sailaja Puttagunta

Sep 7, 2022

Increased rates of extended-spectrum beta-lactamase isolates in patients hospitalized with culture-positive urinary Enterobacterales in the United States: 2011 – 2020

Steven I. Aronina,, Michael W. Dunne, Kalvin C. Yu, Janet A. Watts, Vikas Gupta

Apr 29, 2022

Regional Differences in Antibiotic-resistant Enterobacterales Urine Isolates in the United States: 2018-2020

Steven I. Aronin, Vikas Gupta, Michael W. Dunne, Janet A. Watts, Kalvin C. Yu

Mar 29, 2022

Sulopenem: An Intravenous and Oral Penem for the Treatment of Urinary Tract Infections Due to Multidrug‑Resistant Bacteria

George G. Zhanel · Marianna Pozdirca · Alyssa R. Golden · Courtney K. Lawrence · Sheryl Zelenitsky · Liam Berry · Frank Schweizer · Denice Bay · Heather Adam · Michael A. Zhanel · Philippe Lagace‑Wiens · Andrew Walkty · Neal Irfan · Kurt Naber · Joseph P. Lynch III · James A. Karlowsky

Mar 16, 2022

A multicenter analysis of trends in resistance in urinary Enterobacterales isolates from ambulatory patients in the United States: 2011–2020

Michael W. Dunne, Steven I. Aronin, Kalvin C. Yu, Janet A. Watts & Vikas Gupta

Feb 28, 2022

Impact of Empirical Antibiotic Therapy on Outcomes of Outpatient Urinary Tract Infection Due to Nonsusceptible Enterobacterales

Michael W. Dunne, Sailaja Puttagunta, Steven I. Aronin, Stephen Brossette, John Murray, Vikas Gupta
Microbiology Spectrum

Feb 9, 2022